Neupanex® & Time-Release Melatonin – $250

(41 customer reviews)
1 Box of Neupanex and 1 Bottle of Time-Release Melatonin is included.
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In scientific terms, Neupanex is a patented nutraceutical dietary supplement that contains a precise blend of “neuro-nutrients” designed to support the body’s natural process of converting endogenous stem cells into neurons and supporting the connections within the brain. 

In other words, Neupanex uses your brain’s natural resources and capabilities to support and connect neurons for brain health.


Melatonin, the sleep aid naturally produced by our brains to induce restful sleep, is not only your best friend for a good night’s sleep but also a potent antioxidant, backed by scientific research. That’s why we’ve incorporated it into Dr. Clarke’s patented Neuro Protocol, taking your sleep experience to the next level.

But that’s not all; we’ve gone the extra mile by offering you low-dose (1.5 mg) time-release capsules. Why time-release, you ask? Because it replicates the rhythm of a natural sleep cycle. Unlike regular melatonin, which quickly floods your bloodstream and dissipates, our time-release formula ensures a gradual release, giving you the most optimal sleep support possible.

Why Neupanex™?

Support Your Brain Health

Neupanex contains ingredients that, individually have been scientifically shown to be both neuro-supportive and neuroregenerative. Which means they support your brain cells and help grow new ones. This is effective in promoting natural, neurocognitive processes in the brain.

Neuro Nutrients

Neupanex contains a scientifically structured blend of over 17 different antioxidants and nutraceuticals to support cognitive health. Neupanex’s ingredients are hand-selected by Dr. Lewis Clarke, a physician with over 30 years of clinical and hospital expertise in Rehab and Physical Medicine, as well as a Doctorate in Neuropharmacology and Cell Biology.

Made In the USA From Globally-Sourced Ingredients

Neupanex was formulated and developed in Houston, TX, and is always manufactured in the United States using premium globally sourced ingredients. We take great pride in producing Neupanex in compliance with FDA’s current good manufacturing practices and regulations.

Benefits Of Neupanex®

Support Healthy brain function

Promote short and long-term memory, attention span, and your brain’s ability to communicate and function with itself.


Help you focus on complex tasks and think more clearly.

How Does Neupanex® Help?

Our groundbreaking nutraceutical, Neupanex, is a combination of supplements that help strengthen the brain’s mechanisms and ability to support its natural regenerative process.

How To Take Neupanex®

Easy as 1,2,3:

Our powerful supplement is super easy to take! Simply mix one packet of Neupanex per day in your favorite beverage like water, milk, fruit juice or a smoothie.

The Story Behind Neupanex®

Neupanex® arose out of necessity for Dr. Lewis Clarke during his 30 years in specialty rehabilitation hospitals and his desire to provide nutritional support to help maintain healthy neural function to his aging patients.

His “Neuro-protocol” as it became known, consisted of vitamins, supplements, and nutraceuticals based on his knowledge of neuropharmacology and biochemistry to support the heath of the brain.

Individuals who have used Dr. Clarke’s Neupanex® have benefited from its ingredients to support motor, socialization, and cognitive health.

Frequently Asked Questions

  • What is Neupanex®?

    Neupanex® is a proprietary combination of ingredients endogenous (naturally occurring) in the brain and is designed to support brain and cognitive function processes.

  • How does Neupanex® work?
    Neupanex® targets specific places in the brain by supporting and promoting:
    *Scavenging of free radicals
    *Support of healthy cells
    *Providing antioxidant support
    *Supporting neuron to neuron communication at the cellular level
    *Promoting growth and development of nervous system tissue
    *Facilitating natural brain function

  • Can I take Neupanex® with other medications?
    The components of Neupanex® are generally safe ingredients and should not interfere with other medications. However, you should consult with your physician prior to using Neupanex®.

  • How long does it take Neupanex® to work and what results will I see?
    As with all dietary supplements, it takes time before you will see any benefit from taking the products. We recommend that you try it for at least 30-days.

  • Are there any side effects with Neupanex®?
    The most common side effects from taking Neupanex® is occasional upset stomach due to the amounts of vitamins and supplements that make up the compound.

  • When should I take Neupanex?
    Our recommendation for maximizing the benefit of Neupanex® is to take it right after a meal. Neupanex contains CoQ10, Vitamin D, Vitamin K2, and other fat soluble vitamins and supplements that are best absorbed when taken with food on the stomach. This also helps increase absorption.

  • Can my child take Neupanex?
    Our label claims state that children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. If you contact us, we will not comment on off-label uses nor be able to legally provide Neupanex to you if we’re aware of its off-label use.

  • Can I replace my current regimen of vitamin supplements with Neupanex®?
    Many supplements and nutraceuticals could be eliminated from your regimen by taking Neupanex®.

  • Is Neupanex® covered under insurance?
    Most medical plans do not cover dietary supplements but you can check with your insurance company.

“Neupanex is the culmination of my four decades of work and research inside the chemistry of the human brain. Formulated to include natural compounds demonstrated in current scientific publications to support brain health, I believe it is the best neurocognititve supplement for your brain.”

Dr. Lewis Clarke

41 reviews for Neupanex® & Time-Release Melatonin - $250

  1. James L (verified owner)

    I was skeptical at first but Neupanex has exceeded my expectations. My wife notices the difference as well in my ability to communicate. As long as she’s happy, then I’m happy!

  2. Rachel D (verified owner)

    I’ve tried other supplements in the past, but Neupanex is the only one that’s had a noticeable impact on my cognitive function. A little pricey but I’m a believer.

  3. Margaret G (verified owner)

    Neupanex was recommended by my doctor. It’s truly remarkable how much it’s improved my cognitive function. This is the best supplement I’ve found on the market today.

  4. James B (verified owner)

    Neupanex has helped me feel more alert and focused, but I wish the effects were a bit more immediate.

  5. Cheryl R (verified owner)

    I’ve been using Neupanex for a few weeks now, and the results are noticeable. My productivity and focus has soared, and I feel more mentally agile throughout the day. I plan to stay on it for a while and might even see what a packet every other day can do for me.

  6. James F (verified owner)

    Neupanex has given me the mental edge I’ve been looking for. I feel like my mental endurance is back. Thanks, Dr. Clarke

  7. Kathleen R (verified owner)

    Neupanex is worth every penny! I feel like I’m firing on all cylinders since incorporating it into my regimen a couple months ago.

  8. David A (verified owner)

    Neupanex has had a moderate impact on my cognitive function. While I’ve noticed some improvement, it hasn’t been as significant as I’d hoped.

  9. James F (verified owner)

    I’ve been using it every night and I’ve seen tremendous results just within the 1st month. The only complaint I have is it has melatonin in it but I hear that they’re taking it out with the next batch so I’m looking forward to trying that.

  10. Elise H (verified owner)

    I’m happy with Neupanex overall. It’s a good product.

  11. Pat C (verified owner)

    My husband is responding very well to this Neupanex. Thank you Dr. Clarke. He loves it!

  12. Damien S (verified owner)

    Neupanex has exceeded my expectations. I’m amazed at how much more focused and alert I feel.

  13. Megan G (verified owner)

    Too much melatonin for me

  14. Joel A (verified owner)

    Almost perfect! Neupanex has definitely improved my cognitive function, but it took a little time to see the full effects.

  15. Bryan T (verified owner)

    I was looking for a natural way to improve my mother’s cognitive function as she is up there in age. Bottom line, this supplement has exceeded my expectations. Expensive, yes, but it works. She’s not repeating herself, she’s remembering where she put things, and her bouts of anger have subsided. We are about to the end of the 2nd box and will be ordering a 3rd here shortly.

  16. Michael T (verified owner)

    I found Dr. Clarke and Neupanex through a friend of a friend. Watched a few of his videos and took the plunge. I’ve tried a lot of different supplements for brain function, but this one is by far the best. I haven’t felt this sharp in 20 years.

  17. Vedad P (verified owner)

    I was skeptical at first, but after taking this supplement for a few weeks, I can honestly say it’s made a huge difference in my productivity and mental clarity. The price is high but I haven’t felt this way on anything else. I will keep taking it until I can’t afford it anymore

  18. Christel B (verified owner)

    My husband and I have been using this product nightly for a couple of years and are very happy with the results. We definitely notice a difference when we miss our nightly regimen.

  19. Linda L (verified owner)

    I was told by a friend that this was the best thing on the market for an aging brain. I gave it a try and it took about a month for me to feel the difference. But the difference was so great, that I bought it for both me and my husband. He likes taking it because it doesn’t have any pills. We are in our 60s

  20. Donna A (verified owner)

    I have been using Neupanex for several weeks now and have noticed a significant improvement in my cognitive function. I feel more energized on a daily basis and I feel 100% more organized. The powder has a delicious orange flavor and is easy to incorporate into my daily routine. I highly recommend Neupanex for those looking for something that actually works.

  21. Brendan D (verified owner)

    Neupanex has been a stress reliever for me. My mind feels ready to tackle the day and I’m able to handle challenging situations without getting overloaded like I used to.

  22. Lonnie F (verified owner)

    I have been taking Neupanex since beginning my rehabilitation with Dr. Clarke to help my mobility. Dr. Clarke introduced me to this miracle supplement that I feel has played a huge role in my recovery. Almost immediately after starting the supplement I had measurable improvement. It has been months now and I feel like I am getting stronger everyday. I will continue with this journey in my life with the help of this wonder supplement. Thank you Dr. Clarke for giving me hope and the tools to help me in what has been the biggest challenge of my life. I will be forever grateful.

  23. Kathy Y (verified owner)

    After 2020, I developed significant difficulties with memory, ability to plan, difficulty with focus, difficulties performing highly demanding job tasks, sleeping difficulties, and chronic fatigue. I was also feeling depressed and scared because I could not keep up with my highly demanding job. I tried to sleep all day and as a vitamin enthusiast, I took all kinds of vitamins, but nothing worked consistently. I was feeling hopeless about my future. I did not buy Neupanex right-a-way because I thought I was too young. But after much suffering, in 2022, I decided to call Dr. Clarke’s office and bought a box of Neupanex. After 30 days, I was most happy about being able to get a full night’s sleep, feeling positive mood, improved sustained focus, ability to plan, multi-tasking, more energy, and better memory. I had tried the over-the-counter-supplements like melatonin, but I just did not get the same sleep quality as being on the Neupanex. It has been more than two months since I have been taking Neupanex, and I am very happy to share that I have regained enough brain power to resume my ambitious goals and dreams. I am so thankful for Dr. Clarke’s formula so I can have a quality life ahead. On a side note, I probably will keep on taking Neupanex due to a family history of brain aging and being on menopause. I recently learned the significant drop in female hormones at menopause has deleterious effect on female brains. I like to call Neupanex my brain protector.

  24. Debbie F (verified owner)

    I purchased this for my aging Father and I can tell a difference when he’s taking it and when he’s not. The best way I can describe it is he is less forgetful and is able to keep up with our conversation.

  25. Asal S (verified owner)

    I had the privilege of meeting part of Dr. Clarke’s team at an expo and since I work in the wellness industry as a holistic consultant, I asked for a sample of Neupanex to try. The packet was sitting on my kitchen counter until one day very recently when I woke up with immense anxiety and it got more intense as hours went by. Sitting in meditation, walking, breathing exercises, journalling, stretching, you name it, is what I did and the anxiety wasn’t calming down. Accepting that it would be the state of my health the next day or so, I had a sudden hunch to grab the packet, dissolved the contents in water and had it in a couple of gulps. The taste was intense but I could sense the ingredients kicking in and yes it worked like magic. My nervous system calmed down immediately and it was apparent that Neupanex came to my rescue. I see it as an effective supplement for deficiencies, sudden or chronic. I’m most impressed and grateful for how it helped me.

  26. Scott C (verified owner)

    This is the best cognitive supplement I’ve ever taken. Worth it

  27. Carrie T (verified owner)

    Five stars! Finally something that works!

  28. Sombra W (verified owner)

    My Mother has been taking Neupanex for nearly 30 days. I have noticed that she has an easier time recalling information that, a few weeks ago, would have taken a lot of coaxing and contextualizing to obtain. Specifically, in assisting her with managing her finances it’s usually difficult for her to remember what checks she has written, to whom and for what purpose. However, most recently I was pleasantly surprised that she could recall with very little prodding to whom she’d written a check, the amount and the service received.

    Moreover, my older sister reported that Mom was able to have an hour-long conversation with her without struggling for words or looping through and repeating the same things over and over, which is usually the case.

    Lastly, my younger sister reported an uptick in Mom’s mood most recently along with better sleeping patterns. Overall, we’re happy to see improvements so quickly and look forward to seeing how continued use will impact our Mom’s quality of life. I’m giving 4 stars for now and will update my review after another month.

  29. Bill B (verified owner)

    I have been a patient of Dr. Clarks for 20 years. He has always been great and a leader in finding new ways to help me improve. Before he developed the Neupanex product I was taking many of the supplements in pill form and had some good results. With Neupanex I have seen a greater improvement in my focus and energy levels and have been able to move to just this supplement eliminating all of those daily pills. It is easy to take, just mix with any liquid the package and drink. I would recommend this product to all that want to feel better mental and physically. It has worked great for me.

  30. Will B (verified owner)

    I was worried about my cognitive health after playing sports my entire life. I tried everything under the moon with no real benefit until I found Dr. Clarke and his Neupanex supplement. When I tried it out I was thinking to myself, “I’ve tried everything else, what do I have to lose.” That decision changed my life. My focus returned, my social anxiety went away and I was able to clearly articulate my thoughts once again. I became a machine. This is all because I stepped outside of the box and tried something that wasn’t pharmaceutically based. I now take it when I feel like I need a “power up,” but for the most part, my cognitive concerns have gone away.

  31. Josh B (verified owner)

    I originally started taking Neupanex 4 years ago when Dr. Clarke first gave it to my wife. I was starting to show some memory issues with my advanced age so I thought it might be a good idea to get started. I have been a regular user ever since. Since then my daughters will comment if I come off of it, saying that I’m slower to think through problems and that I keep telling the same Dad jokes over and over again. I do notice if I come off of it for a couple of days that I’m not as sharp but it’s hard to tell sometimes since I’m the one taking it.

    My family swears by it and my daughters see the difference so I’m sticking with it.

  32. Bill T (verified owner)

    I’ve been a Neupanex user for a little while now. I’ve stopped and started a few times for unrelated reasons, so I can attest to the effects that accompany it’s use. More importantly, my wife is a healthcare professional who independently observes those effects.

    What I notice primarily with Neupanex is a calming effect. I sleep well and my working memory has improved. Irritability is improved as well. More importantly, I’m using Neupanex to support my cognitive health in the future.

  33. Mike K (verified owner)

    The past few years I have been really troubled by my cognitive health due my time in the Army. Short term memory and my vocabulary is where I really noticed the problems. My wife noticed we would have a conversation, agree on something, and I couldn’t recall the conversation, agreement, or would recall it not like we had discussed. This was all documented by video to prove it had taken place, because I thought she was messing with me.
    Some former team mates caught wind of Neupanex. I called and talked to Chris Clarke, he was extremely helpful in answering questions and getting me the answers I needed answered prior to starting Neupanex. Needless to say, starting Neupanex was the best thing I’ve done for myself. Especially in regards to my cognitive abilities.

    After starting, the first thing I noticed was the impact on my sleep. After years of only sleeping a few hours a night, and not feeling rested when I woke up, I began getting 5-6 hours of quality sleep and feeling refreshed in the AM.

    Shortly after I noticed I was in much better control of my emotions, primarily my anger. In addition my mood overall has improved greatly and I’m excited about feeling like me again.

    Next I noticed my short term memory improved, and have been able to recall conversations, events, and numbers I haven’t been able to recall like i used to. As i continue to use Neupanex, the above mentioned things are only getting better.

    My teammates/brothers are reporting nearly identical improvements. With that, its positively affecting home life and relationships.

    For any Vets out there concerned with their neurological health for any reason, I highly recommend NEUPANEX. If your Improvement is half as good as mine, its completely worth it!

    I’m beyond thankful for Dr. Clarke’s formula, because I’m getting my brain back!!!!!

    Eternally grateful!

  34. Brenda C (verified owner)

    Amazing – massive improvement in how I feel and my WAVi scan results- THANK YOU

  35. Shawn K (verified owner)

    A few months ago I began experiencing a serious mental and cognitive exhaustion…about 2 months ago my wife said enough was enough..she told me to see Dr. Clarke and get his opinion…he gladly gave it and informed us about Nuepanex. We were willing to try and are super glad we did. My wife is no longer repeating every conversation, I am less confused, and my children find me more tolerable. I would recommend Nuepanex to anyone who wants to better their brain.

  36. David B (verified owner)

    I haven’t felt this clear in over a decade. I’m impressed with the relatively quick results

  37. Janice S (verified owner)

    A world of difference! My husband has been a patient of Dr. Clarke for several years for his brain health. What was most noticeable to me was the difference Neupanex made for him in his mood and mental state. I then personally began experiencing my own mood changes. After talking with Dr. Clarke, he recommended I also take Neupanex. Two days later, my mood was elevated and I felt more like myself than I had in years. After a period of time, I began experiencing better recall of words I wanted to use in sentences, as well as other random things that I would not have normally been able to recall. My husband and I now have our Neupanex cocktail hour each night along with a great night of sleep induced by the melatonin in Dr. Clarke’s wonderful supplement!

  38. Beth W

    After watching Dr. Clarke’s video on YouTube about Neupanex, I decided to give it a try. I’m glad I did because the improvements I’m seeing in both me and my husband are exceeding my expectations. I will be buying again.

  39. Carlos A (verified owner)

    The product works, it just doesn’t taste good

  40. Patricia M (verified owner)

    The powder did not mix well. I requested a refund.

  41. Julie R (verified owner)

    I originally started Neupanex to help my memory issues. What surprised me is that did it not only improve that, but it felt like a mental fog lifted. The taste could be improved but I’m overall happy with the outcome.

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